通過高效的微波輔助氮-硫酰基化和硫酯交換制備硫酯化修飾的糖肽
Efficient Microwave-Assisted Tandem N- to S-Acyl Transfer and Thioester Exchange for the Preparation of a Glycosylated Peptide Thioester
Abstract: A peptide carrying a mercaptomethylatedproline derivative at the C-terminus was prepared by solid-phase peptide synthesis(SPPS) and converted to the thioester of 3-mercaptopropionic acid(MPA) by aqueous MPA under microwave irradiation conditions. This post-SPPS thioesterification reaction was successfully applied to the synthesis of a glycopeptidethioester composed of 25 amino acid (AA) residues, which was then used for the preparation of a 61-AA glycopeptide by the thioester condensation method.
通過高效的微波輔助加熱進行串聯反應，先進行氮-硫酰基化的轉移后進行硫酯交換，從而制備硫酯化修飾的糖肽。
通過固相合成技術（SPPS）合成一條在碳端含有巰甲基脯氨酸的多肽，并且在微波輻射下用3-巰基丙酸（MPA）水溶液進行硫酯交換。在25個氨基酸長的硫酯化糖肽的合成中，成功的應用了該硫酯交換反應，然后用硫酯的縮合方法合成了一條61個氨基酸長的糖肽。
原文出處：
Efficient Microwave-Assisted Tandem N- to S-Acyl Transfer and Thioester Exchange for the Preparation of a Glycosylated Peptide Thioester
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