基因芯片技術已被廣泛地應用于生命科學研究的各個領域。安捷倫科技有限公司將于2008年9月18日和19日分別在北京和上海舉辦基因芯片技術應用講座。分別就miRNA 和CGH芯片技術在腫瘤等研究中的最新應用展開介紹。此次講座邀請了:

Aberrant miRNA Expression in Human Breast Oncogenesis
by Alan Dombkowski, Ph.D.

Abstract:
Breast cancer is believed to develop in a multistep process with premalignant lesions preceding invasive carcinoma. While a growing body of recent work has demonstrated the role of microRNAs in cancer, little is known about the role of microRNAs in precancerous events that precede malignant transformation.In this work we used Agilent miRNA microarray platform to characterize miRNA expression changes associated with breast oncogenesis using a multistep cell line model that mimics the progression of breast cancer, from benign to premalignant to malignant transformation, and with corresponding mouse xenografts. Additionally, we used a bioinformatics tool developed in our laboratory, miR-AT, to identify biological processes and pathways associated with transcripts targeted by the miRNAs.


Integrative Analysis of Genomic Imbalances in Cancer

By Nallasivam Palanisamy, Ph.D.

Abstract:
Recurring non-random chromosome aberrations have been identified in hematological malignancies (leukemia and lymphoma) and soft tissue sarcomas. Among the various clonal aberrations, e.g. gene amplifications,deletions, inversions and duplicalions, chromosome lranslocations have been shown to have an important role in cancer development and they have been used as markers for diagnosis, prognosis and prediction of response to treatment . Current challenge is to understand the genetic complexity of solid tumors, because recurring chromosome abnormalities are difficult to ascertain in solid tumors by conventional karyotyping due to difficulties in chromosome preparation, poor morphology and high complexity of karyotype and clonal heterogeneity. High density oligonucleotide array-based comparative genomic hybridization (array CGH) is emerging as a powerful method for comprehensive analysis of unbalanced chromosome aberrations. In this presentation I will discuss the application of array CGH technology in solid tumor cancer research for the discovery of novel molecular markers.



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Email報名：jing_fang@agilent.com
電話咨詢：8008203278，021－23017650

注冊：本活動全程免費，席次有限，敬請立即報名！注冊截止日期：2008年9月15日

日期：
北京：9/18（星期四）
北京東方花園飯店三層玉蘭廳
北京東直門南大街6號

上海：9/19（星期五）
上海好望角大飯店五樓周仁廳
上海市肇嘉浜路500號

日程安排
8：45－9：00 簽到
9：00－11：00 基因芯片技術講座


安捷倫科技公司上海分公司
網址:http://www.agilent.com.cn