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51 次 Alamethicin(丙甲菌素)的膜通道形成機理及其在膜互作、抗菌中的應用 2025-7-18
膜活性肽（Membrane active pept）是一類能夠與生物膜相互作用并改變膜性質的特殊肽類，可通過與細胞膜相互作用來發揮其生物活性，其中Alamethicin（丙甲菌素，AbMole，M53709）自被發現以來，因
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60 次 c-MET靶點的特性及相關小分子抑制劑、雙抗和ADC藥物研發進展 2025-7-18
c-MET 靶點自 1984 年被發現以來，經歷了漫長的發展歷程，近年來，由于基礎科研和臨床研究的諸多新的進展和發現讓c-Met靶向藥物的研發重新吸引了眾人目光。c-MET 靶點的特性與癌癥關聯c-MET 是由
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109 次 細胞間質上皮轉換因子c-Met的結構功能及靶向藥物在腫瘤中的應用 2025-7-17
引言c-Met全稱cellular-mesenchymal epithelial transition factor（細胞間質上皮轉換因子），為受體酪氨酸激酶家族成員。c-Met信號通路對胚胎發育和產后器官再生期間的侵襲性生長具有關鍵作用。
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176 次 KLF4 和 AMPK 在內皮細胞中脈動切應力抑制糖酵解過程中的作用 2025-7-16
Roles of KLF4 and AMPK in the inhibition of glycolysis by pulsatile shear stress in endothelial cellsKeywords: AMPK; KLF4; epigenetics; GCKR; glycolysis.內皮細胞覆蓋動脈管腔并直接接
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217 次 拉伸通過增強成纖維細胞中內皮素受體B和TRPC3 的表達來促進傷口收縮 2025-7-15
Stretching Promotes Wound Contraction Through Enhanced Expression of Endothelin Receptor B and TRPC3 in FibroblastsKeywords: Stretching; Wound contraction; Endothelin Receptor B; T
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245 次 壓力響應型 miRNA - 5703 的過表達抑制壓力誘導的肝癌生長和轉移 2025-7-9
Overexpression of pressure-responsive miRNA-5703 inhibits pressure-induced growth and metastasis of liver cancerKeywords: liver cancer; metastasis; miRNA-5703; portal hypertension;
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229 次 成纖維細胞中張力敏感的 HOX 基因表達用于差異瘢痕形成 2025-7-8
Tension-sensitive HOX gene expression in fibroblasts for differential scar formationKeywords: Scar formation, Hypertrophic scar; Keloid; Wound healing; Tension; Tension change; Ten
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301 次 C/EBPβ 拮抗劑誘導巨噬細胞促炎極化增強抗腫瘤免疫 2025-7-3
The C/EBPβ antagonist peptide lucicebtide (ST101) induces macrophage polarization toward a pro-inflammatory phenotype and enhances anti-tumor immune responsesKeywords: C/EBP&b
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345 次 小鼠主動脈應力激活平滑肌細胞適應性程序維持強度防動脈瘤和夾層 2025-6-30
Aortic Stress Activates an Adaptive Program in Thoracic Aortic Smooth Muscle Cells That Maintains Aortic Strength and Protects Against Aneurysm and Dissection in MiceKeywords: aort
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411 次 成骨細胞線粒體氧化應激或自噬減少不足以模擬衰老對骨機械反應性損害 2025-6-24
Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsivenessKeywords:
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249 次 苔蘚抑素-1（Bryostatin-1）通過抑制內皮細胞自噬改善動脈功能 2025-6-24
Bryostatin-1 improves function in arteries with suppressed endothelial cell autophagyKeywords: Aging; Bryostatin-1; Endothelial cell; Nitric oxide.內皮功能障礙是心血管衰老的標志，內
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292 次 Piezo1 對抗與衰老相關的皮質骨丟失 2025-6-24
Piezo1 opposes age-associated cortical bone lossKeywords: Piezo1; age-associated bone loss; endocortical bone resorption; mechanical stimulation.衰老會導致松質骨和皮質間隔的骨質流失
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284 次 機械激活的間充質衍生骨細胞通過細胞外囊泡介導的機制驅動血管生成 2025-6-23
Mechanically activated mesenchymal-derived bone cells drive vessel formation via an extracellular vesicle mediated mechanismKeywords: Osteoblast; VEGF; angiogenesis; mechanobiology
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210 次 血管炎性疾病和內皮表型 2025-6-17
Vascular Inflammatory Diseases and Endothelial PhenotypesKeywords: EC phenotypes; endothelial cell; inflammation; vascular diseases.內皮細胞排列在管腔表面，充當分隔血液和周圍組織的
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172 次 微管蛋白乙酰化增強機械應力下小梁網細胞的微管穩定性 2025-6-16
Tubulin Acetylation Enhances Microtubule Stability in Trabecular Meshwork Cells Under Mechanical StressKeywords: trabecular meshwork, glaucoma, tubulin acetylation, mechanical stre
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354 次 拉伸誘導的內皮細胞單層損傷的相關研究 2025-6-10
Stretch-induced damage in endothelial monolayersKeywords: Aging; Cell mechanics; Endothelium; Mechanobiology; Senescence; Stretch.由于血流的脈動性，包括流體剪切力、壓力和循環拉伸在
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388 次 視網膜神經節細胞經IL-12-SCGF-β串擾誘導干細胞衍生的神經保護作用 2025-6-9
Retinal ganglion cells induce stem cell-derived neuroprotection via IL-12 to SCGF-β crosstalkKWS：Retinal ganglion cells；stem cell；neuroprotection；IL-12；SCGF-β；cross
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453 次 血管內皮-間充質串擾通過 Notch 信號驅動人成骨細胞的成骨分化 2025-6-4
Endothelial-mesenchymal crosstalk drives osteogenic differentiation of human osteoblasts through Notch signalingKeywords: Co-culture; Endothelial cells; Notch signaling; Osteoblast
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374 次 TRPV4 抑制劑和機械負荷對減輕炎癥的協同作用 2025-6-3
Synergetic role of TRPV4 inhibitor and mechanical loading on reducing inflammationKeywords: anti-inflammatory phenotype; inhibition, mechanical loading; macrophage polarization; mi
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419 次 I 類 PI3Ks 激活小梁網細胞中拉伸誘導的自噬 2025-5-27
Class I PI3Ks activate stretch-induced autophagy in trabecular meshwork cellsKeywords: Autophagy; Glaucoma; Mechanical stress; PI3K; Primary cilia; Trabecular meshwork.眼壓升高（IO
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